synthesis and antimicrobial activity of some new 1,3,4-thiadiazole derivatives合成及抗菌活性的一些新的1,3,4-thiadiazole衍生品.pdf

Molecules 2012, 17, 14625-14636; doi:10.3390/molecules171214625 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives Thoraya A. Farghaly, Magda A. Abdallah * and Mohamed R. Abdel Aziz Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt * Author to whom correspondence should be addressed; E-Mail: mkamalh2009@. Received: 16 October 2012; in revised form: 23 November 2012 / Accepted: 26 November 2012 / Published: 10 December 2012 Abstract: New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine. Also, some new heterocycles incorporating 1,3,4-thiadiazole ring were obtained by reaction of 1,3,4-thiadiazolenaminones 1 with nitrogen-nucleophiles like hydrazine hydrate, 3-amino-1,2,4-triazole and 2-aminobenzimidazole. The structure of the new products was established based on elemental and spectral analysis. The relation between the structure of the products and their activity towards some microorganisms was studied and promising results were obtained. Keywords: antimicrobial activity; enaminone; 1,3,4-thiadiazole; hydrazonoyl halides 1. Introduction Recently, the chemistry of enaminones has received considerable attention due to