synthesis and antimicrobial evaluation of some pyrazole derivatives合成和抗菌评估一些吡唑衍生物.pdf

Molecules 2012, 17, 4962-4971; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives Essam Mohamed Sharshira 1,* and Nagwa Mohamed Mahrous Hamada 2,* 1 Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt 2 Department of Chemistry, Faculty of Education, Alexandria University, Alexandria 21526, Egypt * Authors to whom correspondence should be addressed; E-Mails: dressamsharshira@ (E.M.S.); nagwahamada2002@ (N.M.M.H.). Received: 20 February 2012; in revised form: 23 March 2012 / Accepted: 18 April 2012 / Published: 30 April 2012 Abstract: Reaction of a series of (E)-3-phenyl-4-(p -substituted phenyl)-3-buten-2-ones with p -sulfamylphenyl hydrazine in glacial acetic acid gave the corresponding hydrazones, subsequent treatment of which with 30% HCl afforded pyrazole-1-sulphonamides. On the other hand, refluxing of chalcones with either thiosemicarbazide or isonicotinic acid hydrazide in ethanol containing a few drops of acetic acid gave pyrazoline-1- thiocarboxamides and isonicotinoyl pyrazolines, respectively. The structures of the synthesized compounds were determined on the basis of their elemental analyses and spectroscopic data. The antimicrobial activity of the newly isolated heterocyclic compounds was evaluated against Gram-positive, Gr