synthesis and antimicrobial activity of new 4-heteroarylamino coumarin derivatives containing nitrogen and sulfur as heteroatoms合成及抗菌活性的新4-heteroarylamino香豆素衍生物含有氮、硫杂原子.pdf

Molecules 2010, 15, 2246-2256; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms 1 2, 1 3 Biljana R. Dekić , Niko S. Radulović *, Vidoslav S. Dekić , Rastko D. Vukićević and Radosav M. Palić2 1 Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia; E-Mail: dekic@ (V.D.) 2 Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia; E-Mail: radosavpalic@ (R.P.) 3 Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia; E-Mail: vuk@kg.ac.yu (R.V.) * Author to whom correspondence should be addressed; E-Mail: vangelis0703@; Tel.: +381-18-533-014; Fax: +381-18-533-015. Received: 17 March 2010; in revised form: 26 March 2010 / Accepted: 29 March 2010 / Published: 30 March 2010 Abstract: Synthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk