synthesis and antimicrobial activity of some new quinoxaline derivatives一些新的喹喔啉衍生物的合成及抗菌活性.pdf

Pharmaceuticals 2010, 3, 2416-2425; doi:10.3390/ph3082416 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives Dharmchand Prasad Singh 1,*, Sanjay Kumar Deivedi 1, Syed Riaz Hashim 1 2 and Ram Gopal Singhal 1 Department of Pharmaceutical Chemistry, College of Pharmacy, Institute of Foreign Trade and Management, Moradabad - 244001, India; E-Mails: sanjaydeivedi@yahoo.co.in (S.K.D.); sriaz_hashim@ (S.R.H.) 2 School of Pharmaceutical Sciences, Shobhit University, Meerut, India; E-Mail: drrgsinghal@ (R.G.S.) * Author to whom correspondence should be addressed; E-Mail: dcp_singh@; Tel.: +91-983-708-5047; Fax: +91-591-236-0818. Received: 25 May 2010; in revised form: 13 July 2010 / Accepted: 16 July 2010 / Published: 30 July 2010 Abstract: 2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C2 chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases conta