synthesis and biological activity of some new pyrazoline and pyrrolo[3,4-c]pyrazole-4,6-dione derivatives reaction of nitrilimines with some dipolarophiles合成和生物活性的一些新的pyrazoline和pyrrolo[3上]pyrazole-4 6-dione衍生品与一些dipolarophiles nitrilimines反应.pdf

Molecules 2008, 13, 1011-1024 molecules ISSN 1420-3049 © 2008 by MDPI /molecules Full Paper Synthesis and Biological Activity of Some New Pyrazoline and Pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives: Reaction of Nitrilimines with Some Dipolarophiles Nada M. Abunada 1,*, Hamdi M. Hassaneen 2, Nadia G. Kandile 3 and Omar A. Miqdad 1 1 Department of Chemistry, Faculty of Applied Sciences, Al-Aqsa University, 76888 Gaza, Palestine; E-mail: miqdadomar@ (O. A. Miqdad) 2 Department of Chemistry, Faculty of Science, Cairo University, Egypt; E-mail: hamdi_251@ (H. M. Hassaneen) 3 Department of Chemistry, University College for Women, Ain Shams University, Heliopolis, Cairo, Egypt; E-mail: nadiaghk@ (N. G. Kandile) *Author to whom correspondence should be addressed; E-mail: nadanadannrs@. Received: 8 April 2008; in revised form: 22 April 2008 / Accepted: 22 April 2008 / Published: 29 April 2008 Abstract: Several 1,3-diaryl-5-(cyano-, aminocarbonyl- and ethoxycarbonyl-)-2- pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione and 1,3,4,5-tetraaryl-2-pyrazoline derivatives were prepared by the reaction of nitrilimine with different dipolarophilic reagents. The new compounds were characterized using IR, 1H-NMR, 13C-NMR and mass spectra. Biological screening of some compounds is reported. Keywords: Pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione, nitrilimine, dipolarophile, biological activity. Introduction Considerable attention has been focused on pyrazolines and substituted pyrazolines due to their interesting biologic