synthesis of a new group of aliphatic hydrazide derivatives and the correlations between their molecular structure and biological activity合成一个新组的脂肪族酰肼衍生品和他们的分子结构和生物活性之间的相关性.pdf

Molecules 2012, 17, 3560-3573; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity Małgorzata Kostecka Department of Chemistry, University of Life Sciences in Lublin, ul. Akademicka 15, 20-950 Lublin, Poland; E-Mail: julka-portal@wp.pl; Tel.: +48-081-445-68-46 Received: 25 January 2012; in revised form: 24 February 2012 / Accepted: 14 March 2012 / Published: 22 March 2012 Abstract: In view of the growing demand for new compounds showing biological activity against pathogenic microorganisms, such as pathogenic and phytopathogenic fungi, the objective of this study was to synthesize a new group of aliphatic and aromatic derivatives of hydrazide. In consequence of the reactions observed during synthesis, the resulting compounds retained their linear structure. Their structure and lipophilicity, measured by high-performance liquid chromatography (HPLC), were analyzed. Correlations were determined between the compounds’ molecular parameters and biological activity against Fusarium solani and Fusarium oxysporum fungi. The investigated compounds were also examined for their antifungal activity against Aspergillus fumigatus . The obtained results indicate that compounds with fluorine-containing substituents penetrate the cell structure more effectively and are characterized b