single nucleotide polymorphisms of toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma单核苷酸多态性的toll样受体4降低发展肝细胞癌的风险.pdf

Single Nucleotide Polymorphisms of Toll-Like Receptor 4 Decrease the Risk of Development of Hepatocellular Carcinoma 1. 2. 1,3 1,3 1,3 3 3 Shi Minmin , Xu Xiaoqian , Chen Hao *, Shen Baiyong , Deng Xiaxing , Xie Junjie , Zhan Xi , Zhao Jianquan3, Jiang Songyao3 1 Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, 2 Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China, 3 Department of Surgery, Ruijin Hospital, Shanghai Jiaoton University School of Medicine, Shanghai, People’s Republic of China Abstract Background: Toll-like receptor 4 (TLR4) is a key innate immunity receptor that initiates an inflammatory response. Growing evidence suggests that mutation of TLR4 gene may play a role in the development of cancers. This study aimed to investigate the temporal relationship of single nucleotide polymorphisms of TLR4 and the risk of hepatocellular carcinoma, a single center-based case-control study was conducted. Methods: A systematic genetic analysis of sequence variants of TLR4 by evaluating ten single-nucleotide polymorphisms was performed from 216 hepatocellular carcinoma cases and 228 controls. Results: Six single nucleotide polymorphisms of the TLR4 in the 59-untranslated region and intron were associated with risk of hepatocellular carcinoma. Individuals carrying the heterozygous genotypes for the r rs2737190, r rs1927914, rand rs1927911 had significantly decreased risk of hepatocellular carcinoma (adjusted odds ratio [OR], from 0.527 to 0.578, P,0.01) comparing with those carrying wild