a at single nucleotide polymorphism-358 is required for g at -420 to confer the highest plasma resistin in the general japanese population需要在单核苷酸多态性- 358 g在-420年授予最高的血浆抵抗素一般日本人.pdf

A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer the Highest Plasma Resistin in the General Japanese Population 1,2. 2,3. 1. 4 5 Hiroshi Onuma , Yasuharu Tabara , Ryoichi Kawamura , Takashi Tanaka , Jun Ohashi , Wataru 1 1 1 6 7 2,8 Nishida , Yasunori Takata , Masaaki Ochi , Kazuya Yamada , Ryuichi Kawamoto , Katsuhiko Kohara , Tetsuro Miki2,8, Hideichi Makino1¤, Haruhiko Osawa1,2* 1 Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, 2 Ehime Proteo-Medicine Research Center, Ehime University, Ehime, Japan, 3 Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Ehime, Japan, 4 Laboratory of Molecular Biology, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan, 5 Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan, 6 Department of Health and Nutritional Science, Faculty of Human Health Science, Matsumoto University, Nagano, Japan, 7 Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, 8 Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan Abstract Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin resistance in mice. We previously reported that the G/G genotype of single nucleotide polymorphism (SNP) at 2420 (rs1862513) in the human resistin gene (RETN) increased