xrcc3 gene polymorphism is associated with survival in japanese lung cancer patientsxrcc3基因多态性与在日本肺癌患者生存.pdf

Int. J. Mol. Sci. 2012, 13, 16658-16667; doi:10.3390/ijms131216658 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients Kayo Osawa 1,*, Chiaki Nakarai 1, Kazuya Uchino 2, Masahiro Yoshimura 2, Noriaki Tsubota 3, Juro Takahashi 1 and Yoshiaki Kido 1,4 1 Faculty of Health Sciences, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan; E-Mails: evening-primrose@energy.ocn.ne.jp (C.N.); Jtaka-16-t aka@S4.dion.ne.jp (J.T.); kido@med.kobe-u.ac.jp (Y.K.) 2 Department of General Thoracic Surgery, Hyogo Cancer Center, Akashi 673-0021, Japan; E-Mails: kazuya-uchino@hp.pref.hyogo.jp (K.U.); myoshi@ hp.pref.hyogo.jp (M.Y.) 3 Department of Thoracic Oncology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; E-Mail: ntsubo@ 4 Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan * Author to whom correspondence should be addressed; E-Mail: osawakysr@; Tel.: +81-78-796-4581; Fax: +81-78-796-4509. Received: 28 September 2012; in revised form: 7 November 2012 / Accepted: 28 November 2012 / Published: 5 December 2012 Abstract: We focused on OGG1 Ser326Cys, MUTYH Gln324His, APEX1 Asp148Glu, XRCC1 Arg399Gln, and XRCC3 Thr241Met and examined the relationship between the different genotypes and survival of Japane