smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk吸烟,饮用绿茶,胰岛素样生长因子的基因多态性与肺癌风险.pdf

Smoking, Green Tea Consumption, Genetic Polymorphisms in the Insulin-Like Growth Factors and Lung Cancer Risk 1 2,3 4 5 5 5 I-Hsin Lin , Ming-Lin Ho , Hsuan-Yu Chen , Hong-Shen Lee , Chia-Chen Huang , Yin-Hung Chu , Shiau- 5 5 5 5 5 5,6 Yun Lin , Ya-Ru Deng , Yu-Hao He , Yu-Hui Lien , Chi-Wen Hsu , Ruey-Hong Wong * 1 Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan, 2 Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 3 Division of Pulmonary Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, 4 Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, 5 Department of Public Health, Chung Shan Medical University, Taichung, Taiwan, 6 Department of Occupational Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan Abstract Insulin-like growth factors (IGFs) are mediators of growth hormones; they have an influence on cell proliferation and differentiation. In addition, IGF-binding protein (IGFBP)-3 could suppress the mitogenic action of IGFs. Interestingly, tea polyphenols could substantially reduce IGF1 and increase IGFBP3. In this study, we evaluated the effects of smoking, green tea consumption, as well as IGF1, IGF2, and IGFBP3 polymorphisms, on lung cancer risk. Questionnaires were administered to obtain the subjects’ characteristics, including smoking habits and green tea consumption from 170 primary lung cancer cases and 340 healthy controls. Genotypes for IGF1, IGF2, and IGFBP3 were identified by polymerase chain reaction. Lung c