胰岛素样生长因子（Insulin-like growth factor）.doc

胰岛素样生长因子（Insulin-like growth factor） Insulin-like growth factor Basic concept Shanghai Ya Xi (International) snow America authorized biomedical technology services center marketing P Department Insulin-like growth factors (IGFs) is a class of multifunctional cell proliferation regulating factors. It plays an important role in cell differentiation, proliferation and individual growth and development. This paper reviews the general situation of IGFs and its relationship with growth and development. History of IGFS Growth hormone and Daughaday on 1957 Salmon (growth hormone, referred to as GH) in the process of giving first found in hypophysectomized rats after GH serum can stimulate S into cultured cartilage, but directly into the liquid culture of GH has no effect, so that GH itself can directly stimulate the growth of cartilage, but through a SF role, this factor became known as growth regulator. 1963 Froesh found in the serum insulin like effect on muscle and fat cells are only a small part of the insulin antiserum inhibited the remaining soluble insulin like activity was not inhibited in acidified ethanol, and named NSILAS which is inhibited by insulin like activity (nonsuppressible insulin-like activity). In 1972, Pieron and Temin purified a cytokine from bovine serum that stimulated cell division, called proliferation stimulating activity. After the above three experiments were completed, it was found that the above three substances had an inhibitory insulin-like activity and a growth stimulatory effect. With the development of molecular biology, 1978 people purified two kinds of NSILA (I, II) and found its structure and proinsulin were named as similar, insulin-like growth factor I and II (IGF I, II) to emphasize their homology with insulin structure. It was also confirmed that the sulfation factor and the proliferation stimulating activity were members of the same polypeptide family as IGF. Composition, physical and chemical properties of IGFs system The IGFs