aromatase gene polymorphisms are associated with survival among patients with cardiovascular disease in a sex-specific manner芳香化酶基因多态性与生存相关心血管疾病患者中性别的方式.pdf

Aromatase Gene Polymorphisms Are Associated with Survival among Patients with Cardiovascular Disease in a Sex-Specific Manner 1 2 2 2 2 Amber L. Beitelshees *, Julie A. Johnson , Megan L. Hames , Yan Gong , Rhonda M. Cooper-DeHoff , 3 4 5 6 3 7 Jun Wu , Sharon Cresci , Cynthia X. Ma , Carl J. Pepine , Michael A. Province , John A. Spertus , Howard L. McLeod5 1 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, College Park, Maryland, United States of America, 2 Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida, United States of America, 3 Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Cardiovascular Division and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri, United States of America, 5 Oncology Division, Washington University School of Medicine, St. Louis, Missouri, United States of America, 6 Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, United States of America, 7 Mid America Heart Institute and University of Missouri Kansas City, Kansas City, Missouri, United States of America Abstract Introduction: CYP19A1 encodes aromatase, the enzyme responsible for the conversion of androgens to estrogens, and may play a role in variation in outcomes among men and women with cardiovascular disease. We sought to examine genetic variation in CYP19A1 for its potential role in sex