are cytochrome p450 cyp2c8 and cyp2c9 polymorphisms associated with ibuprofen response in very preterm infants细胞色素p450 cyp2c8和cyp2c9多态性与布洛芬反应非常早产儿.pdf

Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants? 1,6. 2,6. ´ 3,6 3,6 Xavier Durrmeyer , Shushanik Hovhannisyan , Yves Medard , Evelyne Jacqz-Aigrain , Fabrice 1,6 ´ 4,6 5,6 2,6 1,6. 2,6 . Decobert , Jerome Barre , Corinne Alberti , Yannick Aujard , Claude Danan , Olivier Baud * ´ ´ 1 Neonatal Intensive Care Unit, CHI Creteil, France, 2 Neonatal Intensive Care Unit, Robert Debre Children’s Hospital, Paris, France, 3 Department of Pediatric ´ Pharmacology and Pharmacogenetics, CIC INSERM 9202, Robert Debre Children’s Hospital, Paris, France, 4 Clinical Researches Functional Unit, CHI Creteil, France, ´ 5 Clinical Epidemiology Unit, CIC-EC, Robert Debre Children’s Hospital, Paris, France, 6 Fondation PremUP, Paris, France Abstract Background: Patent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%. We test the hypothesis that cytochrome P450 CYP2C8/2C9 polymorphisms may predict ibuprofen response. Methodology/Principal Findings: We studied extremely preterm neonates with haemodynamically significant PDA