contribution of cytochrome p450 and abcb1 genetic variability on methadone pharmacokinetics, dose requirements, and response种代号为abcb1的贡献的细胞色素p450和遗传变异性在美沙酮药物动力学,剂量要求,和响应.pdf

Contribution of Cytochrome P450 and ABCB1 Genetic Variability on Methadone Pharmacokinetics, Dose Requirements, and Response 1,2,3 2,4,5 ´ 1,3 4,6 ` 4,6 Francina Fonseca , Rafael de la Torre *, Laura Dıaz , Antonio Pastor , Elisabet Cuyas , Nieves 4,6 4,5 ´ ´4,6 1,3,7 Pizarro , Olha Khymenets , Magı Farre , Marta Torrens * 1 Institut de Neuropsiquiatria i Addiccions - Parc de Salut Mar, Barcelona, Spain, 2 Universitat Pompeu Fabra (CEXS-UPF), Barcelona, Spain, 3 Disorders by Use of ´ ` Substances Research Group, Neuropsychopharmacology Research Program, Institut Municipal d’Investigacio Medica (IMIM-Hospital del Mar Research Institute), Barcelona, ´ ` Spain, 4 Human Pharmacology and Clinical Neurosciences Research Group, Neuropsychopharmacology Research Program, Institut Municipal d’Investigacio Medica (IMIM- ´ ´ ´ Hospital del Mar Research Institute), Barcelona, Spain, 5 CIBER de Fisiopatologıa de la Obesidad y Nutricion (CB06/03), Hospital Clınico Universitario Santiago de Compostela, Santiago de Compostela, Spain, 6 Pharmacology Department, Autonomous University of Barcelona, Barcelona, Spain, 7 Psychiatric Department, Autonomous University of Barcelona, Barcelona, Spain Abstract Altho