single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers单个和多个剂量药物动力学的海上松树皮提取物(碧萝芷)健康志愿者口服后.pdf

BMC Clinical Pharmacology BioMed Central Research article Open Access Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers 1 1 2 2 Tanja Grimm , Roswitha Skrabala , Zuzana Chovanová , Jana Muchová , 2 2 2 Katarína Sumegová , Anna Liptáková , Zdeňka Ďuračková and Petra Högger*1 Address: 1Institut für Pharmazie und Lebensmittelchemie, Bayerische Julius-Maximilians-Universität, Würzburg, Germany and 2Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Faculty of Medicine, Bratislava, Slovakia Email: Tanja Grimm - hogger@pzlc.uni-wuerzburg.de; Roswitha Skrabala - hogger@pzlc.uni-wuerzburg.de; Zuzana Chovanová - zuzana.chovanova@fmed.uniba.sk; Jana Muchová - zdenka.durackova@fmed.uniba.sk; Katarína Sumegová - zdenka.durackova@fmed.uniba.sk; Anna Liptáková - zdenka.durackova@fmed.uniba.sk; Zdeňka Ď uračková - zdenka.durackova@fmed.uniba.sk; Petra Högger* - hogger@pzlc.uni-wuerzburg.de * Corresponding author Published: 03 August 2006 Received: 04 February 2006 Accepted: 03 August 2006 BMC Clinical Pharmacology 2006, 6:4 doi:10.1186/1472-6904-6-4 This article is available from: /1472-6904/6/4 © 2006 Grimm et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unres