the effect of β-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite m8 in hiv-1-infected patients补充β-carotene奈非那韦的药物动力学的影响及其活性代谢物m8 hiv-1-infected患者.pdf

Molecules 2012, 17, 688-702; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Effect of β-Carotene Supplementation on the Pharmacokinetics of Nelfinavir and Its Active Metabolite M8 in HIV-1-infected Patients Nancy L. Sheehan 1,2,*, Rolf P. G. van Heeswijk 3, Brian C. Foster 4,5, Humayoun Akhtar 6, Neera Singhal 3, Isabelle Seguin 3, Lina DelBalso 2, Marc Bourbeau 7, Bobby M. Chauhan 4,5, 2 8 2 Mohammed-Rachid Boulassel , David M. Burger , Richard G. Lalonde and Donald William Cameron 3,* 1 Faculty of Pharmacy, Universite de Montreal, C.P. 6128, succursale Centre-Ville, Montreal, H3C 3J7, Canada 2 Immunodeficiency Service, McGill University Health Centre, 3650 St. Urbain, Montreal, H2X 2P4, Canada; E-Mails: lina.delbalso@muhc.mcgill.ca (L.D.); rachid.boulass@muhc.mcgill.ca (M.-R.B.); richard.lalonde@muhc.mcgill.ca (R.G.L.) 3 Division of Infectious Diseases, University of Ottawa at the The Ottawa Hospital/Research Institute, 501 Smyth Road, Ottawa, K1H 8L6, Canada; E-Mails: rvheesw1@ (R.P.G.H.); neerasinghal@ (N.S.); iseguin@ottawahospital.on.ca (I.S.) 4 Office of Science Laboratory, Therapeutics Products Program, Health Canada, 0900C2, Ottawa, K1A 0K9, Canada; E-Mails: brian.foster@hc-sc.gc.ca (B.C.F.); chauhanbm@ (B.M.C.) 5 Faculty of Medicine, Cellular and Molecular Medicine Department, University of Ottawa, 451 Smyth Road, Room 3206, Ottawa, K1H 8M5, Canada 6 Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, N1G 5C9, Canada