uridine metabolism in hiv-1-infected patients effect of infection, of antiretroviral therapy and of hiv-1art-associated lipodystrophy syndrome尿苷代谢hiv-1-infected患者感染的影响,抗逆转录病毒疗法和hiv-1art-associated脂肪代谢障碍综合症.pdf

Uridine Metabolism in HIV-1-Infected Patients: Effect of Infection, of Antiretroviral Therapy and of HIV-1/ART- Associated Lipodystrophy Syndrome 1 2 1 3 3 Pere Domingo *, Javier Torres-Torronteras , Virginia Pomar , Marta Giralt , Joan Carles Domingo , 1 ´ 3 1 3 Maria del Mar Gutierrez , Jose M. Gallego-Escuredo , Maria Gracia Mateo , Pedro Cano-Soldado , Irene 1 3 4 3 2 Fernandez , Marc¸al Pastor-Anglada , Francesc Vidal , Francesc Villarroya , Antoni Andreu , Ramon Marti2 1 Infectious Diseases Unit, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain, 2 Laboratory of Mitochondrial Disorders, Institut de Recerca Hospital Vall d’Hebron and CIBERER, Barcelona, Spain, 3 Departament de Bioquimica i Biologia Molecular and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain, 4 Infectious Diseases Unit, Hospital Universitari Joan XXIII, Tarragona, Spain Abstract Background: Uridine has been advocated for the treatment of HIV-1/HAART-associated lipodystrophy (HALS), although its metabolism in HIV-1-infected patients is poorly understood. Methods: Plasma uridine concentrations were measured in 35 controls and 221 HIV-1-infected patients and fat uridine in 15 controls and 19 patients. The diagnosis of HALS was performed following the criteria of the Lipodystrophy Severity Gr