decreased heart rate variability in hiv positive patients receiving antiretroviral therapy importance of blood glucose and cholesterolhiv阳性患者的心率变异性降低接受抗逆转录病毒治疗血糖和胆固醇的重要性.pdf

Decreased Heart Rate Variability in HIV Positive Patients Receiving Antiretroviral Therapy: Importance of Blood Glucose and Cholesterol 1 2,3 4 1 2,3 Gro Askgaard , Ulrik Sloth Kristoffersen , Jesper Mehlsen , Gitte Kronborg , Andreas Kjaer , Anne-Mette Lebech1* 1 Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark, 2 Clinic of Clinical Physiology, Nuclear Medicine PET, Rigshospitalet, Copenhagen, Denmark, 3 Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark, 4 Department of Clinical Physiology Nuclear Medicine, Frederiksberg University Hospital, Frederiksberg, Denmark Abstract The presence of autonomic dysfunction in HIV patients is largely unknown. Early studies found autonomic dysfunction in patients with AIDS. Antiretroviral combination therapy (ART) has dramatically changed the course of the disease and improved prognosis and decreased morbidity. Aim: To evaluate whether autonomic dysfunction is present in an ART treated HIV population and if so to identify factors of importance. Methods: HIV patients receiving ART for at least 12 months (n = 97) and an age-matched control group of healthy volunteers (n = 52) were included. All were non-diabetic and had never received medication for hypertension. Following a 10 min resting period a 15 min ECG recording was performed. Heart-rate variability (HRV) analysis was performed in accordance with current guidelines and data reported as mean [interquartile range]. Results: Mean normal-to-normal (NN) and total HRV measured as standard deviation of normal-to-normal (SDNN) was lower in HIV patients compared to controls