cross-sectional detection of acute hiv infection timing of transmission, inflammation and antiretroviral therapy横断面检测急性感染艾滋病毒的传播时机,炎症和抗逆转录病毒治疗.pdf

Cross-Sectional Detection of Acute HIV Infection: Timing of Transmission, Inflammation and Antiretroviral Therapy 1 2 1 2 1 3,4 Cynthia Gay *, Oliver Dibben , Jeffrey A. Anderson , Andrea Stacey , Ashley J. Mayo , Philip J. Norris , 1 5 5 5 6 1 JoAnn D. Kuruc , Jesus F. Salazar-Gonzalez , Hui Li , Brandon F. Keele , Charles Hicks , David Margolis , 6 6 1 5 5 Guido Ferrari , Barton Haynes , Ronald Swanstrom , George M. Shaw , Beatrice H. Hahn , Joseph J. 1 2 1 Eron , Persephone Borrow , Myron S. Cohen 1 Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America, 2 Nuffield Department of Clinical Medicine, University of Oxford, Weatherall Institute for Molecular Medicine, Oxford, United Kingdom, 3 Blood Systems Research Institute, San Francisco, California, United States of America, 4 University of California San Francisco, San Francisco, California, United States of America, 5 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 6 Duke University, Durham, North Carolina, United States of America Abstract Background: Acute HIV infection (AHI) is a critical phase of infection when irreparable damage to the immune system occurs and subjects are very infectious. We studied subjects with AHI