antiretroviral pre-exposure prophylaxis prevents vaginal transmission of hiv-1 in humanized blt mice抗逆转录病毒暴露前预防防止阴道传播hiv - 1在人性化blt老鼠.pdf

PLoS MEDICINE Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice 1 2 1 1 1 1 Paul W. Denton , Jacob D. Estes , Zhifeng Sun , Florence A. Othieno , Bangdong L. Wei , Anja K. Wege , 1 3 2 1* Daniel A. Powell , Deborah Payne , Ashley T. Haase , J. Victor Garcia 1 Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, 2 Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America, 3 Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America Funding: This work has been A B S T R A C T supported in part with federal funds from National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) grants Background AI028246 (ATH), AI071940, CA082055 and AI039416 (JVG), and Worldwide, vaginal transmission now accounts for more than half of newly acquired HIV-1 the Department of Obstetrics and infections. Despite the urgency to develop and implement novel approaches capable of Gynecology’s Tissue Procurement preventing HIV transmission, this process has been hindered by the lack of adequate small Facility of the University of Texas Southwestern Medical Center at animal models for preclinical efficacy and safety te