attrition among human immunodeficiency virus (hiv)- infected patients initiating antiretroviral therapy in china, 2003–2010消耗人类免疫缺陷病毒(hiv)感染患者开始抗逆转录病毒疗法在中国,2003 - 2010.pdf

Attrition among Human Immunodeficiency Virus (HIV)- Infected Patients Initiating Antiretroviral Therapy in China, 2003–2010 1,3 1,2 1,2 1 3 2 3 Hao Zhu , Sonia Napravnik , Joseph Eron , Stephen Cole , Ye Ma , David Wohl , Zhihui Dou , 3 3 3 1,2 . 3,4 . Yao Zhang , Zhongfu Liu , Decai Zhao , Myron Cohen * , Fujie Zhang * 1 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, United States of America, 2 Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, United States of America, 3 National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China, 4 Beijing Ditan Hospital Capital Medical University, Beijing, China Abstract Background: Mortality and morbidity from HIV have dramatically decreased in both high- and low-income countries. However, some patients may not benefit from combination antiretroviral therapy (cART) because of inadequate access to HIV care, including attrition after care initiation. Methodology/Principal Findings: The study population included all HIV-infected patients receiving cART through the Chinese National Free Antiretroviral Treatment Program from 1 January 2003 to 31 December 2010 (n = 106,542). We evaluated retention in HIV care and used multivariable Cox proportional hazard models to identify independent factors predictive of attrition. The cumulative probability of attrition from cART initiation was 9% at 1