association of human papillomavirus infection and abnormal anal cytology among hiv-infected msm in beijing, china协会的人类乳头瘤病毒感染和肛门异常细胞学在男男性接触者感染艾滋病毒的北京,中国.pdf

Association of Human Papillomavirus Infection and Abnormal Anal Cytology among HIV-Infected MSM in Beijing, China 1. 1. 2 3 4 1 1 Yu Yang , Xiangwei Li , Zhihui Zhang , Han-Zhu Qian , Yuhua Ruan , Feng Zhou , Cong Gao , 1 1 1 Mufei Li , Qi Jin *, Lei Gao * 1 MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China, 2 Hospital of Cancer, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3 Vanderbilt Institute for Global Health, and Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 4 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Abstract Background: In the recent years, dramatic increases in HIV transmission among men who have sex with men (MSM) have been observed in China. Human papillomavirus (HPV) infection related anal cancer is more common among HIV-infected MSM as compared to the general population. However, HPV infection and anal cytology has been rarely studied in HIV- infected MSM in China. Methods: HIV-infected MSM in Beijing, China were invited to participate in this study between January and April 2011. Anal swabs were collected for examining cytology and HPV genotypes. Results: Ninety-five eligible participants with complete questionnaire and laboratory data were included in the analyses. Thirty six of them (37.9%) showed abnormal anal cytology as follows: atypical squamous cells of undetermined significance (ASC-US) in 19 (20.0%), atypic