antibodies that induce phagocytosis of malaria infected erythrocytes effect of hiv infection and correlation with clinical outcomes疟疾感染的抗体诱导吞噬红细胞艾滋病毒感染和相关临床结果的影响.pdf

Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes ´ 1,2 3,4 3,5 6 Ricardo Ataıde *, Victor Mwapasa , Malcolm E. Molyneux , Steven R. Meshnick , Stephen J. Rogerson1 1 Department of Medicine (RMH/WH), University of Melbourne, Post Office Royal Melbourne Hospital, Melbourne, Victoria, Australia, 2 Graduate Program in Areas of Basic and Applied Biology (GABBA), Universidade do Porto, Porto, Portugal, 3 Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi, 4 Department of Community Health, College of Medicine, University of Malawi, Blantyre, Malawi, 5 School of Tropical Medicine, University of Liverpool, Liverpool, United Kingdom, 6 Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America Abstract HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2VSA were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2VSA did not. Phagocytic antibodies to CS2VSA are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identification of correlates of immunity. ´ Ci