the cerebrospinal fluid proteome in hiv infection change associated with disease severity艾滋病毒感染的脑脊液蛋白质组变化与疾病严重程度有关.pdf

Angel et al. Clinical Proteomics 2012, 9:3 /content/9/1/3 CLINICAL PROTEOMICS RESEARCH Open Access The cerebrospinal fluid proteome in HIV infection: change associated with disease severity 1 1 2,5 1 3 2 Thomas E Angel , Jon M Jacobs , Serena S Spudich , Marina A Gritsenko , Dietmar Fuchs , Teri Liegler , 4 1 2 1* Henrik Zetterberg , David G Camp II , Richard W Price and Richard D Smith * Correspondence: rds@ Abstract 1Biological Sciences Division, Pacific Northwest National Laboratory, Background: Central nervous system (CNS) infection is a nearly universal feature of Richland, WA, USA Full list of author information is untreated systemic HIV infection with a clinical spectrum that ranges from chronic available at the end of the article asymptomatic infection to severe cognitive and motor dysfunction. Analysis of cerebrospinal fluid (CSF) has played an important part in defining the character of this evolving infection and response to treatment. To further characterize CNS HIV infection and its effects, we applied advanced high-throughput proteomic methods to CSF to identify novel proteins and their changes with disease progression and treatment. Results: After esta