culture conversion among hiv co-infected multidrug-resistant tuberculosis patients in tugela ferry, south africa文化转换在tugela ferry艾滋病毒合并感染耐多药结核病患者中,南非.pdf

Culture Conversion Among HIV Co-Infected Multidrug- Resistant Tuberculosis Patients in Tugela Ferry, South Africa James C. M. Brust1,2*, Melissa Lygizos2,3, Krisda Chaiyachati2,3, Michelle Scott2,4, Theo L. van der 2,5 2,5 1 6,7 2,5 7 Merwe , Anthony P. Moll , Xuan Li , Marian Loveday , Sheila A. Bamber , Umesh G. Lalloo , Gerald H. Friedland2,8, N. Sarita Shah1,2,9, Neel R. Gandhi1,2,9 1 Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Tugela Ferry Care and Research Collaboration (TF CARES), Tugela Ferry, South Africa, 3 University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America, 4 Harvard University School of Medicine, Boston, Massachusetts, United States of America, 5 Philanjalo, Tugela Ferry, South Africa, 6 Health Systems Research Unit, Medical Research Council, Cape Town, South Africa, 7 Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, 8 Yale University School of Medicine, New Haven, Connecticut, United States of America, 9 Department of Epidemiology and Population Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, United States of America Abstract Background: Little is known about the time to sputum culture conversion in MDR-TB patients co-infected with HIV, although such patients have, historically, had poor outcomes. We describe culture conversion rates among MDR-TB patients with and without HIV-co-infection in a TB-endemic, high-HIV prevalent, resource-limited setting. Methods: Patients with culture-proven MDR-TB were treated with a standardized second-line regimen. Spu