the antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis抗精神病药物甲硫哒嗪显示承诺在小鼠模型的耐多药结核病治疗活动.pdf

The Antipsychotic Thioridazine Shows Promising Therapeutic Activity in a Mouse Model of Multidrug- Resistant Tuberculosis 1,2 3 3 3 Dick van Soolingen *, Rogelio Hernandez-Pando , Hector Orozco , Diana Aguilar , 4 5 1,4 4 Cecile Magis-Escurra , Leonard Amaral , Jakko van Ingen , Martin J. Boeree 1 National Mycobacteria Reference Laboratory, Laboratories for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands, 2 Departments of Clinical Microbiology and Respiratory Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, ` 3 Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico, 4 University Centre for Chronic Diseases Dekkerswald, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 5 Mycobacteriology Unit, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal Abstract Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon. To address these problems we revisited a classical observation, the applicability of phenothiazines as antimicrobial drugs. Within this pharmacological class we selected thioridazine, which is most efficacious and least toxic, when used as an antipsychotic drug. We tested thioridazine monotherap