burden of new and recurrent tuberculosis in a major south african city stratified by age and hiv-status新的负担和复发肺结核在南非的一个主要城市分层按年龄和艾滋病毒状况.pdf

Burden of New and Recurrent Tuberculosis in a Major South African City Stratified by Age and HIV-Status 1,2,3 1,2,4 5 1,2 1,2 Robin Wood , Stephen D. Lawn , Judy Caldwell , Richard Kaplan , Keren Middelkoop , Linda- Gail Bekker1,2* 1 Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa, 2 Department of Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa, 3 Department of Science and Technology/National Research Foundation, Centre of Excellence in Epidemiological Modeling and Analysis, University of Stellenbosch, Cape Town, South Africa, 4 Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, 5 City of Cape Town Department of Health, Cape Town, South Africa Abstract Aim: To describe the burden of tuberculosis (TB) in Cape Town by calculating TB incidence rates stratified by age and HIV- status, assessing the contribution of retreatment disease and estimating the cumulative lifetime TB risk in HIV-negative individuals. Methods: Details of TB cases were abstracted from the 2009 electronic TB register. Population denominators were estimated from census data and actuarial estimates of HIV prevalence, allowing calculation of age-specific and HIV-stratified TB notification rates. Results: The 2009 mid-year population was 3,443,010 (3,241,508 HIV-negative and 201,502 HIV-positive individuals). There were 29,478 newly notified TB cases of which 56% were laboratory confirmed. HIV status was recorded for 87% of cases and