burden of pneumonia and meningitis caused by streptococcus pneumoniae in china among children under 5 years of age a systematic literature review肺炎链球菌引起的肺炎和脑膜炎的负担在中国5岁以下儿童中一个系统的文献回顾.pdf

Burden of Pneumonia and Meningitis Caused by Streptococcus pneumoniae in China among Children under 5 Years of Age: A Systematic Literature Review 1. 2. 3. 1 2 2 2 Ying Chen , Wei Deng , Song-Mei Wang , Qi-Mei Mo , Huan Jia , Qun Wang , Song-Guang Li , Xiang 2 2 2 2 4 4 1,5 Li , Bao-Dong Yao , Cheng-Jun Liu , Yi-Qiang Zhan , Chen Ji , Anna Lena Lopez , Xuan-Yi Wang * 1 Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China, 2 Department of Health Statistics and Social Medicine, School of Public Health, Fudan University, Shanghai, People’s Republic of China, 3 Laboratory of Medical Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China, 4 Pfizer Inc., New York, New York, United States of America, 5 Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract Background and Methods: To understand the burden and epidemiology of Streptococcus pneumoniae disease among children between 1 and 59 months of age in China, we conducted a review of literature published between 1980 and 2008 applying standardized algorithms. Because of the absence of population-based surveillance for pneumococcal disease (PD), we identified all-cause pneumonia, bacteremia and meningitis burden, syndromes most commonly associated with S. pneumoniae, and applied the proportion of disease attributable to S. pneumoniae from studies that determined the etiology of these three syndromes to