the effect of 12 weeks anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trial12周的影响anethum graveolens(莳萝)代谢综合征患者的代谢标记;.pdf

Mansouri et al. DARU Journal of Pharmaceutical Sciences 2012, 20:47 /content/20/1/47 RESEARCH ARTICLE Open Access The effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trial 1 1 1,2 1* 1 1 Masoume Mansouri , Neda Nayebi , Abasali keshtkar , Shirin Hasani-Ranjbar , Eghbal Taheri and Bagher Larijani Abstract Background: The clustering of metabolic abnormalities defined as metabolic syndrome is now both a public health and a clinical problem .While interest in herbal medicine has greatly increased, lack of human evidence to support efficacies shown in animals does exist. This clinical trial study designed to investigate whether herbal medicine, Anethum graveolens (dill) extract, could improve metabolic components in patients with metabolic syndrome. Methods: A double-blind, randomized, placebo-controlled trial using a parallel design was conducted. 24 subjects who had metabolic syndrome diagnostic criteria (update of ATP III) were randomly assigned to either dill extract (n = 12) or placebo (n = 12) for 3 months. Results: Across lipid component of metabolic syndrome, no significant differences in triglyceride (TG) concentration and high density lipoprotein cholesterol were seen between the two groups. However TG improved significantly from baseline (257.0 vs. 201.5p = 0.01) with dill treatment but such a significant effect was not observed in placebo group. Moreover, no significant differences in waist circumference, blood pressure and fasting blood sugar were seen between two groups after 3 months follow up period. Conclusion: In this small clinical trial in patients with me