文献_Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1,.pdf

BMC Cancer BioMed Central Research article Open Access Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk † † Lara Bethke , Emily Webb , Gabrielle Sellick, Matthew Rudd, Stephen Penegar, Laura Withey, Mobshra Qureshi and Richard Houlston* Address: Section of Cancer Genetics, Institute of Cancer Research, Surrey, UK Email: Lara Bethke - lara.bethke@icr.ac.uk; Emily Webb - emily.webb@icr.ac.uk; Gabrielle Sellick - gabrielle.sellick@icr.ac.uk; Matthew Rudd - matthew.rudd@icr.ac.uk; Stephen Penegar - stephen.penegar@icr.ac.uk; Laura Withey - laura.withey@icr.ac.uk; Mobshra Qureshi - mobshra.qureshi@icr.ac.uk; Richard Houlston* - richard.houlston@icr.ac.uk * Corresponding author †Equal contributors Published: 5 July 2007 Received: 23 June 2006 Accepted: 5 July 2007 BMC Cancer 2007, 7:123 doi:10.1186/1471-2407-7-123 This article is available from: /1471-2407/7/123 © 2007 Bethke et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones. Methods: To inves