文献_Polymorphisms of CYP1A1 , CYP2E1 , GSTM1 , GSTT1 , and TP53 Genes.pdf

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 119:249–256 (2002) Polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, and TP53 Genes in Amerindians Pedro A. Gaspar,1 Mara H. Hutz,1 Francisco M. Salzano,1 Kim Hill,2 A. Magdalena Hurtado,2 M. Luiza Petzl-Erler,3 Luiza T. Tsuneto,3 and Tania A. Weimer1,4* 1 Departamento de Gene´tica, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil 2Department of Anthropology, University of New Mexico, Albuquerque, New Mexico 87131 3Departamento de Gene´tica, Universidade Federal do Parana´, 81531-990 Curitiba, Brazil 4Departmento de Biology, Universidade Luterana do Brasil, Canoas, RS, Brazil KEY WORDS gene diversity; South American Indians; molecular markers ABSTRACT Polymorphisms at the TP53, cytochrome alleles and against GST null genotypes during America’s P-450 (CYP), and glutathione S-transferase (GST) genes colonization. Intrapopulation diversity varied from 0.19 are related to cancer susceptibility and present high di- (Guarani) to 0.38 (Surui), and 90% of the total diversity versity in allele frequencies among ethnic groups. This was due to the variability within populations. The rela- study concerns the CYP2E1, GSTM1, and GSTT1 poly- tionships between these Amerindians and with other eth- morphisms in seven Amerindian populations (Xavante, nic groups were evaluated based on DA distances and the Guarani, Ache´, Wai Wai, Zoro´, Surui, and Gavia˜o). Poly- neighbor-joining method. Low correlation was observed morphic sites at CYP1A1 and TP53 were also studied in between genetic relationships and geographic distances or the Ache´ and Guarani tribes and compared with previous linguistic groups. In the TP53 comparison with other eth- results about these