the (ctg)n polymorphism in the notch4 gene is not associated with schizophrenia in japanese individuals(玻纤)n在新的高度多态性基因与精神分裂症相关的不是日本人.pdf

BMC Psychiatry (2001) 1:1 /1471-244X/1/1 BMC Psychiatry (2001) 1:1 Research article The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals 1 2 1 1 Koubun Imai* , Shoji Harada , Yoichi Kawanishi , Hirokazu Tachikawa , Takehito Okubo2 and Toshihito Suzuki1 Address: 1Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan and 2Institute of Community Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan E-mail: Koubun Imai* - zc6k-imi@asahi-net.or.jp; Shoji Harada - sjharada@md.tsukuba.ac.jp; Yoichi Kawanishi - qb2y-kwns@asahi- net.or.jp; Hirokazu Tachikawa - mg8@ea.mbn.or.jp; Takehito Okubo - ta-okubo@bc4.so-net.ne.jp; Toshihito Suzuki - psuzukit@md.tsukuba.ac.jp *Corresponding author Published: 4 June 2001 Received: 18 April 2001 Accepted: 4 June 2001 BMC Psychiatry 2001, 1:1 This article is available from: /1471-244X/1/1 (c) 2001 Imai et al, licensee BioMed Central Ltd. Abstract Background: The human NOTCH4 gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiological roles. In a British linkage study, NOTCH4 gene polymorphisms were highly associated with schizophrenia. In a Japanese case-control association study, however, these polymorphisms did not show significant associations with schizophrenia. We conducted a case-control study with Japanese subjects to explore an association between the triplet repeat