a ？436ca polymorphism in the human fas gene promoter associated with severe childhood malaria 436 ca在人类fas基因启动子多态性与儿童严重疟疾.pdf

A 2436C.A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria 1,2 3 1,2 ¨ 1 1 Kathrin Schuldt *, Cosima C. Kretz , Christian Timmann , Jurgen Sievertsen , Christa Ehmen , Claudia 1 4 5 2 1 2 ¨ 4 Esser , Wibke Loag , Daniel Ansong , Carmen Dering , Jennifer Evans , Andreas Ziegler , Jurgen May , 3 5 1 Peter H. Krammer , Tsiri Agbenyega , Rolf D. Horstmann 1 Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2 Institute of Medical Biometry and Statistics, University at ¨ ¨ Lubeck, University Hospital Schleswig-Holstein, Lubeck, Germany, 3 Division of Immunogenetics, German Cancer Research Centre, Heidelberg, Germany, 4 Infectious Disease Epidemiology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 5 School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Abstract Human genetics and immune responses are considered to critically influence the outcome of malaria infections including life-threatening syndromes caused by Plasmodium falciparum. An important role in immune regulation is assigned to the apoptosis-signaling cell surface receptor CD95 (Fas, APO-1), encoded by the gene FAS. Here, a candidate-gene association study including variant discovery at the FAS gene locus was carried out in a case-control group comprising 1,195