decreased dengue replication and an increased anti-viral humoral response with the use of combined toll-like receptor 3 and 78 agonists in macaques减少登革热复制和增加抗病毒体液反应使用结合toll样受体3和78年猕猴受体激动剂.pdf

Decreased Dengue Replication and an Increased Anti- viral Humoral Response with the use of Combined Toll- Like Receptor 3 and 7/8 Agonists in Macaques 1,2,3 ´ 1 1 ´ 1 Carlos A. Sariol *, Melween I. Martınez , Francheska Rivera , Idia Vanessa Rodrıguez , Petraleigh 1 4 2 5 5 6 Pantoja , Kristina Abel , Teresa Arana , Luis Giavedoni , Vida Hodara , Laura J. White , Yesseinia I. ´ 2 7 1,2 Anglero , Luis J. Montaner , Edmundo N. Kraiselburd 1 Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, United States of America, 2 Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, United States of America, 3 Department of Internal Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, United States of America, 4 Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 5 Departments of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, 6 The Carolina Vaccine Institute, University of North Carolina, Chapel Hill, North Carolina, United States of America, 7 The Wistar Institute, Philadelphia, Pennsylvania, United States of America Abstract Background: Pathogenic versus protective outcomes to Dengue virus (DENV) infection are associated with innate immune function. This study aimed to determine the role of increased TLR3- and TLR7/8-mediated innate signali