control of bone mass and remodeling by pth receptor signaling in osteocytes控制的骨量和重塑甲状旁腺素受体信号在骨细胞.pdf

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes 1 1 1 1 1 Charles A. O’Brien *, Lilian I. Plotkin , Carlo Galli , Joseph J. Goellner , Arancha R. Gortazar , Matthew R. 2 2 3 4 5 1 Allen , Alexander G. Robling , Mary Bouxsein , Ernestina Schipani , Charles H. Turner , Robert L. Jilka , 1 1 1 Robert S. Weinstein , Stavros C. Manolagas , Teresita Bellido * 1 Division of Endocrinology, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, 2 Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 3 Department of Orthopedic Surgery, Harvard Medical School, Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, 4 Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 5 Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States of America Abstract Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. Parathyroid hormone (PTH) stimulates bone remodeling and may cause bone loss or bone gain depending on the balance between bone resorption