critical role of neuropeptides bw receptor 1 signaling in social behavior and fear memory关键作用的神经肽bw受体1信号在社交行为和恐惧记忆.pdf

Critical Role of Neuropeptides B/W Receptor 1 Signaling in Social Behavior and Fear Memory 1,2 1 1 1 2,3 1 Ruby Nagata-Kuroiwa , Naoki Furutani , Junko Hara , Mari Hondo , Makoto Ishii , Tomomi Abe , 1 1 2,4 5,6 7 Michihiro Mieda , Natsuko Tsujino , Toshiyuki Motoike , Yuchio Yanagawa , Tomoyuki Kuwaki , Miyuki Yamamoto8, Masashi Yanagisawa2,4, Takeshi Sakurai1,2* 1 Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan, 2 Exploratory Research for Advanced Technology (ERATO) Yanagisawa Orphan Receptor Project, Japan Science and Technology Agency, Tokyo, Japan, 3 Department of Neurology, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York, United States of America, 4 Howard Hughes Medical Institute and Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, 5 Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Japan, 6 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan, 7 Department of Physiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 8 Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan Abstract Neuropeptide B/W receptor 1 (NPBWR1) is a G-protein coupled receptor, which was initially reported as an orphan receptor, and whose