association of genetic loci with blood lipids in the chinese population协会中国人口与血脂基因位点.pdf

Association of Genetic Loci with Blood Lipids in the Chinese Population 1,2. 1. 1 1 1 1 3 Zhou Zhang , Liming Tao , Zhuo Chen , Daizhan Zhou , Mengyuan Kan , Di Zhang , Can Li , Lin 2,3 2 He *, Yun Liu * 1 Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, 2 Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China, 3 Bio-X Center, Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Ministry of Education), Shanghai Jiao Tong University, Shanghai, People’s Republic of China Abstract Background: Recent genome-wide association (GWA) studies have identified a number of novel genetic determinants of blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA studies also exert the same effect on lipid concentrations in the Chinese population. Methods and Results: We conducted a replication study assessing associations between SNPs at 15 loci and blood lipid and lipoprotein concentrations in two Chinese cohorts, comprising 2533 and 2105 individuals respectively. SNPs in APO(A1/C3/ A4/A5), TIMD4-HAVCR1, DOCK7, TRIB1, ABCA1, and TOMM40-APOE showed strong associations with at least one lipids trait, and rs174546 in FADS1/2/3 showed modest association with triglyceride in the Chinese population. Conclusions: We successfully replicated 7 loci associated plasma lipid concentrations in the Chinese population. Our study confirmed the implication of APO(A1/C3/A4/A5), TOMM40-APOE, ABCA1,