association of common genetic variants in the map4k4 locus with prediabetic traits in humans协会共同map4k4位点的遗传变异的前驱糖尿病的人类特征.pdf

Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans 3 1,2, . 1,2,3. 2,3 3 1,2 Tina Sartorius , Harald Staiger , Caroline Ketterer , Martin Heni , Fausto Machicao , Adilson Guilherme4, Harald Grallert2,5, Matthias B. Schulze2,6, Heiner Boeing2,7, Norbert Stefan1,2,3, 1,2,3,8 4 ¨ 1,2,3 Andreas Fritsche , Michael P. Czech , Hans-Ulrich Haring * ¨ ¨ 1 Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tubingen, Tubingen, Germany, 2 German Center for Diabetes Research (DZD), Neuherberg, Germany, 3 Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal ¨ ¨ Medicine, Eberhard Karls University Tubingen, Tubingen, Germany, 4 Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, 5 Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany, 6 Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany, 7 Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany, 8 Division of Nutritional and Preventive M