association of caucasian-identified variants with colorectal cancer risk in singapore chinese协会caucasian-identified变异与结直肠癌风险在新加坡的中国人.pdf

Association of Caucasian-Identified Variants with Colorectal Cancer Risk in Singapore Chinese 1 2 3 3 4 5 Lai Fun Thean , Hui Hua Li , Yik Ying Teo , Woon-Puay Koh , Jian-Min Yuan , Mei Lin Teoh , Poh 1 1 1,3,6 Koon Koh , Choong Leong Tang , Peh Yean Cheah * 1 Department of Colorectal Surgery, Singapore General Hospital, Singapore, 2 Department of Clinical Research, Singapore General Hospital, Singapore, Singapore, 3 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 4 University of Pittsburgh Cancer Institute, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 5 Health Screening Unit, Singapore General Hospital, Singapore Singapore, 6 Duke-National University of Singapore, Graduate Medical School, National University of Singapore, Singapore Abstract Background: Genome-wide association studies (GWAS) in Caucasians have identified fourteen index single nucleotide polymorphisms (iSNPs) that influence colorectal cancer (CRC) risk. 2 Methods: We investigated the role of eleven iSNPs or surrogate SNPs (sSNPs), in high linkage disequilibrium (LD, r $0.8) and within 100 kb vicinity of iSNPs, in 2,000 age- and gender-matched Singapore Chinese (SCH) cases and controls. Results: Only iSNP rs6983267 at 8q24.21 and sSNPs rs6695584, r rs3087967, rs2059254, and rs7226855 at 1q41, 8q23.3, 11q23.1, 16q22.1 and 18q21.1 respectively showed evidence of associ