association of genetic variants of melatonin receptor 1b with gestational plasma glucose level and risk of glucose intolerance in pregnant chinese women褪黑激素受体1 b基因变异协会与妊娠期血糖水平和中国妇女怀孕的葡萄糖耐受不良的风险.pdf

Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women 1 . 2. 3 1 4 5 5 Shunyao Liao * , Yunqiang Liu , Yuande Tan , Lu Gan , Jie Mei , Wenzhong Song , Shu Chi , 6 7 1,8 Xianjue Dong , Xiaojuan Chen , Shaoping Deng * 1 Diabetes Center, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Chengdu, China, 2 Department of Medical Genetics and Division of Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China, 3 College of Life Science, Hunan Normal University, Changsha, Hunan, China, 4 Department of Obstetrics and Gynecology, Sichuan Academy of Medical Science, Sichuan Provincial People’s Hospital, Chengdu, China, 5 Clinical Isotopic Laboratory, Sichuan Academy of Medical Science, Sichuan Provincial People’s Hospital, Chengdu, China, 6 Department of Endocrinology, Chongqing Medical University, Chongqing, China, 7 Department of Surgery, Northwest University Hospital, Chicago, Illinois, United States of America, 8 Human Islet Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Background: This study aimed to explore the association of MTNR1B genetic variants with gestational plasma glucose homeostasis in pregnant Chinese women. Methods: A total of 1,985 pregnant Han Chinese women were recruited and evaluated for gestational glucose tolerance status with a two-step approach. The four MTNR1B variants r rs1387153, rs1447352, and rs2166706 which had