ctx (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetesctx(crosslaps)而不是骨桥蛋白与干扰葡萄糖代谢在妊娠期糖尿病.pdf

CTX (Crosslaps) Rather than Osteopontin Is Associated with Disturbed Glucose Metabolism in Gestational Diabetes 1 1 2 3 4 Yvonne Winhofer , Florian W. Kiefer , Ammon Handisurya , Andrea Tura , Katharina Klein , 5 6 6 3 1 Barbara Schneider , Rodrig Marculescu , Oswald F. Wagner , Giovanni Pacini , Anton Luger , 1,7 1 Thomas M. Stulnig , Alexandra Kautzky-Willer * 1 Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 2 Division of Nephrology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 3 Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy, 4 Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria, 5 CeMSIIS, Section of Medical Statistics, Medical University of Vienna, Vienna, Austria, 6 Clinical Institute for Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Vienna, Austria, 7 Christian Doppler-Laboratory for Cardio- Metabolic Immunotherapy, Medical University of Vienna, Vienna, Austria Abstract Objective: Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin (OPN),