specific variants in the mlh1 gene region may drive dna methylation, loss of protein expression, and msi-h colorectal cancer特定变异的一种基因区域可能推动dna甲基化,蛋白表达,msi-h结肠直肠癌.pdf

Specific Variants in the MLH1 Gene Region May Drive DNA Methylation, Loss of Protein Expression, and MSI-H Colorectal Cancer 1,2,3 4 4,5 1,2,3 3 Miralem Mrkonjic , Nicole M. Roslin , Celia M. Greenwood , Stavroula Raptis , Aaron Pollett , 6 2 4 7 8 Peter W. Laird , Vaijayanti V. Pethe , Theodore Chiang , Darshana Daftary , Elizabeth Dicks , Stephen N. 9 1,2,7,10 8 11 12 Thibodeau , Steven Gallinger , Patrick S. Parfrey , H. Banfield Younghusband , John D. Potter , Thomas J. Hudson13,14,15, John R. McLaughlin2,5,7, Roger C. Green11, Brent W. Zanke7,16, Polly A. Newcomb12, Andrew D. Paterson4,5, Bharati Bapat1,2,3* 1 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, 2 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, 3 Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada, 4 Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada, 5 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada, 6 University of Southern California Epigenome Center, University of Southern California, Los Angeles, California, United States of America, 7 Ontario Familial Colorectal Cancer Registry, Cancer Care Ontario, Toronto, Ontario, Canada, 8 Clinical Epidemiology Unit, Memorial University of