contribution of hogg1 ser326cys polymorphism to the development of prostate cancer in smokers meta-analysis of 2779 cases and 3484 controls发展的贡献hogg1 ser326cys多态性吸烟者荟萃分析的前列腺癌2779例和3484例对照.pdf

Contribution of HOGG1 Ser326Cys Polymorphism to the Development of Prostate Cancer in Smokers: Meta- Analysis of 2779 Cases and 3484 Controls 1,2. 3. 1 1 1 1 1 Bin Xu , Na Tong , Shu-Qiu Chen , Yu Yang , Xiao-Wen Zhang , Jin Liu , Xiang-Nong Hu , Guo-Zhu Sha1, Ming Chen1,2* 1 Department of Urology, Affiliated Zhongda Hospital, Southeast University, Nanjing, China, 2 Surgical Research Center, Medical School, Southeast University, Nanjing, China, 3 Department of Occupational Medicine and Environmental Health, Nanjing Medical University, Nanjing, China Abstract The HOGG1 gene catalyzes the excision of modified bases and removal of DNA damage adducts. It may play an important role in the prevention of carcinogenesis. Ser326Cys polymorphism localizes in exon 7 of the hOGG1 gene. It takes the form of an amino acid substitution, from serine to cysteine, in codon 326. Several epidemiological association studies have been conducted on this polymorphism and its relationship with the risk of prostate cancer. However, results have been conflicting. To resolve this conflict, we conducted a meta-analysis on the association between this polymorphism and prostate cancer, taking into account race, country, sources of controls, and smoking status. A total of nine studies covering 2779 cases and 3484 controls were included in the current meta-analysis. Although no significant association was found between hOGG1 Ser326Cys polymorphism and prostate cancer susceptibility in the pooled analysis, individuals with Ser/ Cys+Cys/Cys genotypes were found to have greater risk of prostate cancer if they were also smokers (OR = 2.66, 95% CI = 1.58 24.47) rather than non-smokers (OR = 2.18, 95% CI = 1.13 24.19), c