association of ccr2-ccr5 haplotypes and ccl3l1 copy number with kawasaki disease, coronary artery lesions, and ivig responses in japanese children协会ccr2-ccr5单和ccl3l1拷贝数与川崎病冠状动脉病变,和丙种球蛋白反应在日本的孩子.pdf

Association of CCR2-CCR5 Haplotypes and CCL3L1 Copy Number with Kawasaki Disease, Coronary Artery Lesions, and IVIG Responses in Japanese Children 1 2 3 4 5 Manju Mamtani , Tomoyo Matsubara , Chisato Shimizu , Susumu Furukawa , Teiji Akagi , Yoshihiro 6 7 8 1 1,9 3 Onouchi , Akira Hata , Akihiro Fujino , Weijing He , Sunil K. Ahuja *, Jane C. Burns 1 South Texas Veterans Health Care System and Department of Medicine, The Veterans Administration Center for AIDS and HIV-1 Infection, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, 2 Department of Pediatrics, Juntendo University Graduate School of Medicine, Chiba, Japan, 3 Department of Pediatrics, Rady Children’s Hospital, University of California San Diego School of Medicine, La Jolla, California, United States of America, 4 Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, 5 Pediatrics Cardiac Care Unit, Okayama University Hospital, Okayama, Japan, 6 Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Kanagawa, Japan, 7 Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan, 8 Department of Surgery, National Center for Child Health and Development, Tokyo, Japan, 9 Departments of Microbiology and Immunology, and Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America Abstract Background: The etiology of Kawasaki Disease (KD) is enigmatic, although an infectious cause is suspected. Polymorphisms in CC chemokine receptor 5 (CCR5) and/or its potent ligand CCL3L1 influence KD susc