丙种球蛋白无反应性川崎病药物治疗临床探析.doc

丙种球蛋白无反应性川崎病药物治疗临床分析 　　[摘要] 目的 观察对于丙种球蛋白无反应性川崎病的药物治疗情况。 方法 选择2012年1月～2015年12月来我院进行治疗的丙种球蛋白无反应性川崎病患儿66例，随机分为观察组和对照组各33例，对照组患儿追加丙种球蛋白，剂量为2 g/（kgd），其余治疗方案同前。观察组在对照组治疗方案的基础上使用甲强龙，5 mg/（kgd），每日1次，口服。待体温恢复正常后，改为泼尼松片口服。比较两组患儿退热时间、黏膜充血消退时间、颈淋巴结肿大消退时间、手足肿胀消退时间。随访3个月，观察两组患儿冠状动脉病变发生情况。 结果 观察组患儿的退热时间、黏膜充血消退时间、颈部淋巴结肿大消退时间以及手足肿胀消退时间均明显短于对照组，差异有统计学意义（P0.05）。 结论 对丙种球蛋白无反应性川崎病患儿应用适量激素治疗，有助于患儿临床症状的迅速消退 [关键词] 丙种球蛋白；无反应性川崎病；甲强龙；临床症状；药物治疗 [中图分类号] R725.4 [文献标识码] B [文章编号] 1673-9701（2016）23-0050-03 [Abstract] Objective To observe the drug therapy of immunoglobin-resistant Kawasaki disease. Methods 66 children patients with immunoglobin-resistant Kawasaki disease who were admitted to our hospital for treatment from January 2012 to December 2015 were selected and randomly assigned to the observation group and the control group， with 33 patients in each group. The children patients in the control group were further given immunoglobin， with the dosage of 2 g/（kg?d）， and other regimens were unchanged. The observation group was orally given methylprednisolone on the basis of the regimen in the control group， with the dosage of 5 mg/（kgd） once a day. When the body temperature was normal， the patients were orally given prednisone tablets. Time of fever abatement， abatement time of mucosal hyperemia， abatement time of neck lymph node enlargement， and abatement time of hand and foot swelling were compared between the two groups. The children patients were followed-up for 3 months， and the occurrence of coronary artery disease was observed in the two groups. Results Time of fever abatement， abatement time of mucosal hyperemia， abatement time of neck lymph node enlargement， and abatement time of hand and foot swelling in the observation group were all significantly shorter than those in the control group， and the differences were statistically significant （P0.05）. Conclusion Application of appropriate amount of hormone in the children patients with immunoglobin-resistant Kawasaki disease is ab