augmented tlr2 expression on monocytes in both human kawasaki disease and a mouse model of coronary arteritis增强单核细胞tlr2表情人类川崎病和冠状动脉炎的小鼠模型.pdf

Augmented TLR2 Expression on Monocytes in both Human Kawasaki Disease and a Mouse Model of Coronary Arteritis 1 1 1 2 1 3 I-Chun Lin , Ho-Chang Kuo , Ying-Jui Lin , Feng-Shen Wang *, Lin Wang , Shun-Chen Huang , Shao- 1 1 4 1 5 5 Ju Chien , Chien-Fu Huang , Chih-Lu Wang , Hong-Ren Yu , Rong-Fu Chen , Kuender D. Yang * 1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and the Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kaohsiung, Taiwan, 2 Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and the Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kaohsiung, Taiwan, 3 Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and the Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kaohsiung, Taiwan, 4 Department of Pediatrics, Po-Jen Hospital, Kaohsiung, Taiwan, 5 Department of Medical Research, Show Chwan Memorial Hospital in Chang Bing, Changhua, Taiwan Abstract Background: Kawasaki disease (KD) of unknown immunopathogenesis is an acute febrile systemic vasculitis and the leading cause of acquired heart diseases in childhood. To search for a better strategy for the prevention and treatment of KD, this study compared and validated human KD immunopathogenesis in a mouse model of Lactobacillus casei cell wall extract (LCWE)-induced coronary arteritis. Methods: Recruited subjects fulfilled the criteria of KD and were admitted for intravenous gamma globulin (IVIG) treatment at the Kaohsiung Chang Gung Memorial Hospital from 2001 to 2009.