the cytokine language of monocytes and macrophages in systemic sclerosis单核细胞和巨噬细胞的细胞因子语言在系统性硬化症.pdf

Christmann and Lafyatis Arthritis Research Therapy 2010, 12:146 /content/12/5/146 EDITORIAL The cytokine language of monocytes and macrophages in systemic sclerosis Romy B Christmann and Robert Lafyatis* See related research by Higashi-Kuwata et al., /content/12/4/R128 More recent studies have shown that SSc monocytes Abstract express allograft inhibitory factor-1 [8]. Data from our Many important observations suggest monocyte/ group indicate that allograft inhibitory factor-1 expres- macrophage involvement in systemic sclerosis (SSc). A sion in circulating monocytes is part of an interferon- high concentration of immune mediators, such as IL-6, responsive gene expression signature in SSc patients [9] IL-10 and IL-13, the ini ltration of mononuclear cells in (RBC and RL, unpublished observations). Strikingly, in af ected organs and the production of autoantibodies patients showing upregulated interferon-responsive genes, suggest that immune system dysfunction drives all CD14+ monocytes expressed increased sialoadhesin, SSc pathogenesis. The recently reported study by suggesting that interferon activates the entire monocyte Higashi-Kuwata and colleagues, in light of other population. In addition, several genes associated with observations, provides further insight into activation of monocyte/macrophage recruitment and diff erentiation macrophages/monocytes in SSc patients, suggesting were overexpressed in recent microarray analyses of SSc that these c