the association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis a longitudinal study软骨下骨囊肿和胫骨软骨体积之间的关系和风险膝骨关节炎患者关节置换的纵向研究.pdf

Tanamas et al. Arthritis Research Therapy 2010, 12:R58 /content/12/2/R58 R E S E A R C H A R T I C L E Open Access Research article The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study 1 1 2 2 3 Stephanie K Tanamas , Anita E Wluka , Jean-Pierre Pelletier , Johanne Martel-Pelletier , François Abram , Yuanyuan Wang 1 1 and Flavia M Cicuttini* Abstract Introduction: To examine the natural history of subchondral bone cysts and to determine whether knee cartilage loss and risk of joint replacement is higher in knees with cysts, compared with those with bone marrow lesions (BMLs) only or those with neither BMLs nor cysts. Methods: The symptomatic knee in 132 subjects with knee osteoarthritis (OA) was imaged by using magnetic resonance imaging at baseline and 2 years later. Tibial cartilage volume, subchondral bone cysts, and BMLs were measured by using validated methods. Knee arthroplasty over a 4-year period was ascertained. Results: Bone cysts were present in 47.7% of subjects, 98.1% of whom also had BMLs. Over a 2-year period, 23.9% of subjects had cysts progress, 13.0% developed new cysts, and 11.4% had cysts regress. Bone cysts at baseline were associated with lower medial and lateral tibial cartilage volume compared with those with BMLs only or those with neither (P for trend 0.004 and 0.001, respectively). Annual medial cartilage volume loss was greatest in those with bone cysts compared with those with BMLs only or those with neither (9.3%, 6.3%, and 2.6%, respectively; P for trend, 0.001). As the severity of bone abnormality in the medi