the determinants of change in tibial plateau bone area in osteoarthritic knees a cohort study变化的决定因素在胫骨平台骨在骨关节炎的膝盖一个队列研究.pdf

Available online /content/7/3/R687 Vol 7 No 3 Open Access Research article The determinants of change in tibial plateau bone area in osteoarthritic knees: a cohort study 1,2 1 1 Yuanyuan Wang , Anita E Wluka and Flavia M Cicuttini 1Department of Epidemiology and PreventiveMedicine, Monash UniversityMedical School, Alfred Hospital, Prahran, Vic 3181, Australia 2Graduate School of IntegrativeMedicine, Swinburne University of Technology, Hawthorn, Vic 3122, Australia Corresponding author: Flavia M Cicuttini, flavia.cicuttini@.au Received: 8 Sep 2004 Revisions requested: 19 Oct 2004 Revisions received: 27 Jan 2005 Accepted: 2 Mar 2005 Published: 31 Mar 2005 Arthritis Research Therapy 2005, 7:R687-R693 (DOI 10.1186/ar1726) This article is online at: /content/7/3/R687 © 2005 Wang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Bone is integral to the pathogenesis of osteoarthritis (OA). per year, respectively. Being male (P = 0.001), having a higher Whether the bone area of the tibial plateau changes over time in body mass index (P = 0.002), and having a higher baseline subjects with knee OA is unknown. We performed a cohort grade of medial joint-space narrowing (P = 0.01) were all study to describe this and identify factors that might influence independently and positively associated with an inc