the determinants of susceptibilityresistance to adjuvant arthritis in ratssusceptibilityresistance的决定因素在大鼠佐剂关节炎.pdf

Available online /content/11/4/239 Review The determinants of susceptibility/resistance to adjuvant arthritis in rats Eugene Y Kim and Kamal D Moudgil Department of Microbiology and Immunology, University of Maryland School of Medicine, HH 323C, 660 West Redwood Street, Baltimore, MD 21201, USA Corresponding author: Kamal D Moudgil, kmoud001@ Published: 7 August 2009 Arthritis Research Therapy 2009, 11:239 (doi:10.1186/ar2755) This article is online at /content/11/4/239 © 2009 BioMed Central Ltd Abstract In the past 10 to 15 years, significant advances have been Adjuvant arthritis (AA) serves as an excellent model for human made in unraveling the mechanisms involved in the initiation rheumatoid arthritis. AA is readily inducible in certain rat strains, but of AA as well as the regulation of AA. Studies comparing the not in others. Susceptibility/resistance to AA is determined by physiological characteristics as well as the immune multiple factors. Among the genetic factors, both MHC and non- responsiveness of AA-susceptible rat strains versus AA- MHC genes contribute to arthritis susceptibility, and specific resistant rat strains have provided critical insights into the quantitative trait loci show association with the severity of the disease process and have thereby contributed to these disease. Differential T-cell proliferative and cytokine responses, as well as antibody responses, to heat-shock proteins are evident advanceme